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IMPaCT-Data: A Federated Precision Medicine Infrastructure Associated with Science and Technology in Spain
Silvia Rodríguez-Mejías1, Fátima Sánchez-Cabo2, Fátima Al-Shahrour3
1Computational Health Informatics Group, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
Studies in Health Technology and Informatics
|May 23, 2026
Summary
Spain is building the IMPaCT Digital Platform (IDP) to create a trusted research environment (TRE) for secure and FAIR data sharing. This infrastructure supports precision medicine initiatives by integrating diverse health data for advanced analysis.
Area of Science:
- Health Informatics
- Precision Medicine
- Bioinformatics
Background:
- The European Health Data Space (EHDS) initiative promotes secure health data sharing across Europe.
- Spain's IMPaCT (Precision Medicine Infrastructure associated with Science and Technology) aligns with EHDS objectives.
- Establishing a Trusted Research Environment (TRE) is crucial for secure and FAIR (Findable, Accessible, Interoperable, Reusable) data handling.
Purpose of the Study:
- To outline the structure and objectives of Spain's IMPaCT initiative.
- To detail the development of the IMPaCT Digital Platform (IDP) as a core component.
- To describe the federated architecture supporting secure data integration and analysis.
Main Methods:
- Structuring IMPaCT into three pillars: IMPaCT-Cohort (Predictive Medicine), IMPaCT-Genomics (Genomic Medicine), and IMPaCT-Data (Data Science).
- IMPaCT-Data leads the development of the IMPaCT Digital Platform (IDP).
- Implementing a federated model for the IDP architecture to integrate clinical, genomic, and imaging data.
Main Results:
- The IMPaCT initiative is establishing a TRE for precision medicine in Spain.
- The IMPaCT Digital Platform (IDP) is under development to integrate diverse health data.
- A federated architecture is defined for the IDP, supporting national projects.
Conclusions:
- IMPaCT is creating a robust infrastructure for precision medicine research in Spain.
- The IDP will facilitate secure and FAIR data sharing and analysis.
- The federated model ensures scalability and interoperability for health data research.
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