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Flipping the Card With Enantiodivergent Organocatalysis
Debora Iapadre1, Alessio Carioscia1, Alessandro Brusa1
1Department of Physical and Chemical Sciences, Consorzio C.I.N.M.P.I.S., INSTM RU, Università degli Studi dell'Aquila, L'Aquila, Italy.
Abstract:
This minireview focuses on recent and most impactful contributions in enantiodivergent organocatalyzed reactions. Four different approaches based on achiral stimuli were examined as inversion strategies: solvent-controlled inversion, achiral reagent or additive-inducted inversion, and minimal catalyst modification, discussing in detail for each example the mechanistic insights behind the chiral inversion. Other strategies to achieve enantiodivergence are also briefly discussed.
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