Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 25, 2026

Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve
06:48

Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve

Published on: November 30, 2018

Nerve Gap Reconstruction.

Casey Imbergamo1, Ellie Moeller2, Sierra Lindsey3

  • 1The Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD.

The Journal of Hand Surgery
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a 3D-Printed Model for Simulating Closed Reduction and Percutaneous Pinning of Unstable Distal Radius Fractures.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews·2026
Same author

Initial Opioid Prescription Is Associated With and Predictive of Prolonged Postoperative Opioid Use in Hand Surgery Patients.

Journal of hand surgery global online·2026
Same author

Outcomes Following Regenerative Peripheral Nerve Interface Surgery and Associations With Preoperative Mental Health: A Retrospective Analysis of Upper-Extremity Neuromas.

Journal of hand surgery global online·2026
Same author

The Effect of Scaphoid Overstuffing on Radiocarpal Contact Pressures.

Hand (New York, N.Y.)·2026
Same author

The Swiss Cheese Effect: A Biomechanical Study of Fifth Metacarpal Structural Integrity After Multiple Kirschner Wire Passes.

Journal of hand surgery global online·2026
Same author

Rotational Stability of One Versus Two Intramedullary Screws for Proximal Phalanx Fractures: A Biomechanical Study.

The Journal of hand surgery·2026
Same journal

Biomechanical Comparison of Metal Versus Suture and Screw Tension Band Technique for Olecranon Fractures.

The Journal of hand surgery·2026
Same journal

Incidence, Timing, and Predictors of Staged Contralateral Carpal Tunnel Release at Minimum Ten-Year Follow-Up from Unilateral Surgery.

The Journal of hand surgery·2026
Same journal

Upper Limb Reconstruction in Arthrogryposis Multiplex Congenita: A Systematic Review.

The Journal of hand surgery·2026
Same journal

Is Generalized Joint Hypermobility a Risk Factor in the Development of Wrist Ganglion Cysts? A Retrospective Case-Control Study.

The Journal of hand surgery·2026
Same journal

The Likelihood of Future Dupuytren Disease Intervention After Initial Treatment in the Same Digit, Another Digit, and Contralateral Hand.

The Journal of hand surgery·2026
Same journal

Outcomes After Treatment of Scaphoid Nonunion With Open Reduction Internal Fixation and Nonvascularized Autograft.

The Journal of hand surgery·2026
See all related articles

Nerve reconstruction using autografts, conduits, or allografts shows similar outcomes for small gaps. Larger gaps require further research to improve nerve repair and regeneration, as current methods yield disappointing results.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Nerve injuries often create gaps too large for direct surgical repair due to tissue loss and scarring.
  • Traditional nerve gap bridging involves autologous nerve grafts, which have drawbacks like donor site morbidity.
  • Advancements include hollow conduits and processed human nerve allografts aiming to improve nerve reconstruction outcomes.

Purpose of the Study:

  • To compare the efficacy of different nerve gap bridging strategies: autograft, hollow conduits, and processed nerve allografts.
  • To evaluate sensory recovery in digital nerve reconstructions across various nerve gap sizes.
  • To identify areas for improvement in nerve repair and regeneration biology.

Main Methods:

  • Review of existing studies comparing nerve autograft, hollow nerve conduits, and processed nerve allografts for nerve gap reconstruction.
Keywords:
Hollow conduitsnerve gap reconstructionnerve regenerationnerve repairprocessed nerve allograft

More Related Videos

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery
05:56

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery

Published on: October 19, 2021

Related Experiment Videos

Last Updated: May 25, 2026

Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve
06:48

Ethanol-Induced Cervical Sympathetic Ganglion Block Applications for Promoting Canine Inferior Alveolar Nerve Regeneration Using an Artificial Nerve

Published on: November 30, 2018

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery
05:56

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery

Published on: October 19, 2021

  • Analysis of sensory recovery data, particularly for digital nerve injuries with varying gap lengths.
  • Synthesis of current understanding regarding nerve repair and regeneration.

    • Main Results:

    • For small digital nerve gaps (<15 mm), sensory recovery is comparable between autograft, hollow conduits, and processed nerve allografts.
    • Processed nerve allografts may offer advantages over hollow conduits for slightly larger nerve gaps.
    • Direct comparison of processed nerve allograft versus autograft across diverse nerve injuries remains unclear.

    Conclusions:

    • While promising, processed nerve allografts' superiority over autografts in various nerve injuries needs further investigation.
    • Current nerve reconstruction techniques, including grafts and conduits, often yield suboptimal results.
    • Advancing the understanding of nerve regeneration biology is crucial for enhancing all nerve repair and reconstruction outcomes.