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Updated: May 25, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
The effects of parity on the maternal microbiome - challenges associated with mouse models
Sondra Turjeman1, Soha Zgairy2, Omry Koren2
1Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel. sondra.turjeman@biu.ac.il.
Abstract:
Understanding how parity shapes the maternal microbiota is critical for advancing maternal and offspring health. We investigated the effects of parity and spacing between births on the maternal microbiota in mice. While maternal age strongly influenced microbiota diversity and composition, parity and lengths of gaps between births showed minimal impact. These findings highlight key model constraints that must be considered when designing longitudinal microbiome studies within and beyond the context of reproduction.
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