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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Traveling with HIV.
Victor Daniel Miron1,2,3,4, Lorenzo Rabbi3,4,5, Sai Keertana Devarapalli6
1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
International travel for people with human immunodeficiency virus (HIV) requires careful planning. Comprehensive pre-travel consultations are crucial for safe international journeys, addressing health, legal, and medication needs.
Area of Science:
- Global Health
- Infectious Diseases
- Travel Medicine
Background:
- International travel is common, presenting risks for preventable illness in travelers.
- People living with human immunodeficiency virus (HIV) face unique challenges during international travel.
- Pre-travel consultations are essential for mitigating health risks.
Purpose of the Study:
- To provide a structured, evidence-informed framework for counseling people living with HIV who travel internationally.
- To outline key domains for safe international travel for individuals with HIV.
- To emphasize individualized assessment and proactive risk mitigation.
Main Methods:
- Review of current literature and clinical guidelines on travel health for people with HIV.
- Identification of key considerations including legal barriers, health evaluations, vaccinations, malaria prevention, and sexual health.
- Development of strategies for managing travel-related health events.
Main Results:
- Legal and structural barriers, including entry restrictions, can impact travel plans and healthcare access for people with HIV.
- Sustained viral suppression on antiretroviral therapy (ART) is critical, requiring planning for uninterrupted medication supply and adherence.
- Potential drug-drug interactions between ART and travel medications (e.g., antimalarials, antibiotics) must be managed.
- Vaccination strategies need to account for immune status and potential reduced immunogenicity.
- Increased sexual risk and exposure to sexually transmitted infections (STIs) require targeted counseling and prevention strategies.
- Destination-specific precautions, like malaria prevention, must be compatible with ART regimens.
Conclusions:
- HIV-informed travel counseling should be integrated into comprehensive HIV care.
- Safe international travel for people with HIV requires a multidisciplinary approach addressing medical, pharmacological, behavioral, and structural factors.
- Proactive planning and risk mitigation are essential to reduce avoidable complications during international travel.
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