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Global prevalence of adenomatoid odontogenic tumor: A systematic review and meta-analysis
Adetayo Aborisade1, Amina Mohammed-Jaji2, Azuka Njokanma3
1Department of Oral Diagnostic Sciences, Bayero University, Kano, Nigeria.
Objectives:
Adenomatoid Odontogenic Tumor (AOT) is a benign encapsulated epithelial odontogenic tumor that contains rosette or duct-like structures and has an indolent behavior. AOT is an uncommon tumor characterized by slow and progressive growth, as well as a non-invasive nature. Being an unusual tumor, the prevalence of AOT has been primarily reported in cross-sectional studies with variations across countries and geographical locations. Understanding of its global prevalence estimate is crucial for understanding the burden of this rare tumor. So, this study aims to update and extend previous knowledge on the epidemiology of this condition.
Methods:
An electronic search was conducted using the following search engines and databases: Web of Science (WOS), Scopus, Google Scholar, PubMed/MEDLINE, and Embase. We adhered to the PRISMA guidelines and utilized the PRISMA checklist. Eligible English studies were reviewed and analyzed. Relevant studies on the prevalence of AOT both in odontogenic tumors and in all documented biopsies were identified and included in the meta-analysis. Random-effects models were used to calculate the pooled prevalence. Where heterogeneity was present, subgroup analysis and meta-regression were conducted to identify sources of heterogeneity in the meta-analysis.
Results:
The meta-analysis included eighty-three eligible studies, providing the global prevalence of AOT as 4.5% of odontogenic tumors and 0.12% of all biopsies. The pooled mean age of presentation was 18.7 years, and a predilection for the female gender, maxilla, and anterior jaw location was observed. With significant heterogeneity, moderator analysis revealed that the continent of publication, decreasing age of presentation, and institution type had a significant impact on the estimated pooled prevalence of AOT.
Conclusion:
The overall global prevalence of AOT at 0.12% corroborates observational studies, indicating that it is a rare odontogenic tumor with notable geographical differences. Standardization of case series and cohort studies will improve the accurate estimation of prevalence in future systematic reviews and meta-analyses.
Protocol And Registration:
The systematic review and meta-analysis were registered with PROSPERO with ID CRD42023491394.