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Interventions to Improve Breast Cancer Preventive Medication Treatment Uptake: A Systematic Review
Sara Jaradat1, Lotanna Ezeja1, Jingjing Qian1
1Auburn University Harrison College of Pharmacy, Auburn, AL.
American Journal of Preventive Medicine
|May 24, 2026
Summary
Improving breast cancer (BC) preventive medication uptake requires comprehensive, multi-level interventions. Integrating healthcare provider counseling and proactive prescribing into routine practice significantly boosts treatment adherence for high-risk individuals.
Area of Science:
- Oncology
- Preventive Medicine
- Health Services Research
Background:
- Selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) are effective in reducing breast cancer (BC) incidence in high-risk individuals.
- Clinical guidelines recommend these preventive medications, yet uptake remains suboptimal.
Purpose of the Study:
- To systematically review interventions aimed at improving the uptake of BC preventive medications among high-risk individuals.
- To identify effective strategies for enhancing adherence to BC preventive therapies.
Main Methods:
- A systematic literature search was conducted across Ovid MEDLINE, Web of Science, and PsychINFO.
- Included experimental and observational studies evaluated interventions to improve BC preventive medication uptake.
- Risk of bias was assessed using NHLBI quality assessment tools.
Main Results:
- Educational and decision aid interventions improved knowledge but had minimal impact on uptake.
- Personalized approaches, including polygenic risk scores (PRSs), showed improved uptake when combined with education.
- Holistic interventions targeting the healthcare system, including provider counseling and proactive prescribing, achieved substantial uptake and adherence.
Conclusions:
- Comprehensive, tailored interventions implemented at multiple care levels and integrated into clinical practice are most effective.
- Translating knowledge into action for BC preventive therapies requires a multi-faceted approach.
- Healthcare system integration is key to improving uptake and adherence of BC preventive treatments.
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