Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specific bile acids can elicit the type-I interferon response through the cGAS-STING pathway.

Cell communication and signaling : CCS·2026
Same author

Genomic characterization of a large-scale chikungunya outbreak in China.

The Journal of infection·2026
Same author

Novel Carborane Based Metal Organic Framework for Record Electronic Specialty Gas C<sub>2</sub>F<sub>6</sub> Purification via Molecular Sieving.

Angewandte Chemie (International ed. in English)·2026
Same author

Precision prevention of colorectal neoplasia in patients undergoing hemorrhoid surgery: an explainable machine learning model for identifying the risk of precancerous neoplastic polyps.

Frontiers in cell and developmental biology·2026
Same author

[Clinical Study and Economic Evaluation of High-Dose Etoposide Combined with Mecapegfilgrastim for Autologous Peripheral Blood Stem Cell Mobilization in Patients with Lymphoma].

Zhongguo shi yan xue ye xue za zhi·2026
Same author

From global to local: ERP repetition effects reveal a configural-to-featural pattern in face processing.

Psychonomic bulletin & review·2026

Related Experiment Video

Updated: May 26, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

Correlation between hyperuricemia and coronary artery calcification.

Zhixiong Zhong1, Fuwen Zhang2, Xinying Hu2

  • 1Department of Cardiovascular Medicine, Shaoguan First People's Hospital, China.

The Journal of International Medical Research
|May 25, 2026
PubMed
Summary
This summary is machine-generated.

High uric acid levels (hyperuricemia) are linked to increased coronary artery calcification. Uric acid promotes this arterial hardening through oxidative stress, inflammation, and cellular changes.

Keywords:
Hyperuricemiacalcium–phosphate metabolism disordercoronary artery calcificationinflammatory responseoxidative stressvascular smooth muscle cells

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Related Experiment Videos

Last Updated: May 26, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Metabolic Disorders

Background:

  • Hyperuricemia, characterized by elevated serum uric acid levels, is increasingly recognized as a potential risk factor for cardiovascular diseases.
  • Coronary artery calcification (CAC) is a significant marker of atherosclerosis and a predictor of cardiovascular events.

Purpose of the Study:

  • To systematically review and synthesize recent scientific evidence on the association between hyperuricemia and the extent of coronary artery calcification.
  • To explore the epidemiological links and underlying mechanistic pathways connecting elevated uric acid to CAC.

Main Methods:

  • A narrative review of scientific literature published within the last five years.
  • Inclusion of epidemiological studies, mechanistic investigations, and clinical trials examining hyperuricemia and CAC.
  • Synthesis of evidence to establish the relationship and identify contributing factors.

Main Results:

  • Consistent epidemiological evidence demonstrates a significant association between higher serum uric acid levels and increased prevalence and progression of CAC.
  • Mechanistic studies reveal multiple pathways: uric acid induces oxidative stress, endothelial dysfunction, vascular smooth muscle cell transformation, and inflammation.
  • These pathways collectively contribute to the development and advancement of coronary artery calcification.

Conclusions:

  • Hyperuricemia is strongly associated with coronary artery calcification.
  • Uric acid plays a direct role in promoting arterial calcification through various pathophysiological mechanisms.
  • Further research and clinical attention are warranted to address the impact of hyperuricemia on cardiovascular health.