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Updated: May 26, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
A Mild and DNA-Compatible Cyclization Strategy for the Construction of [1,2,4]Triazolo[1,5-a]pyridine Scaffolds
Zhaobing Ding1, Feifei Li1, Jun Lu1
1PharmaBlock Sciences (Nanjing), Inc., Nanjing 210032, Jiangsu, China.
Abstract:
Here, we report a mild and DNA-compatible cyclization strategy for the construction of [1,2,4]triazolo[1,5-a]pyridine scaffolds that is well suited for DNA-encoded library (DEL) construction. This reaction proceeds via cyclocondensation of aldehydes with 1,2-diaminopyridinium salt substrates under mild and simple conditions. This method enables the rapid and efficient construction of a series of DNA-encoded libraries containing compounds with a potentially biologically active [1,2,4]triazolo[1,5-a]pyridine scaffold.
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