Related Experiment Video
Updated: May 26, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Diagnostic utility of the platelet-to-thrombin-antithrombin complex ratio in heatstroke: a single-center
Long-Ping He1,2, Shi-Kai Yu1,2, Qing-Wei Lin1,2
1Intensive Care Unit, No. 908th Hospital of Chinese PLA Logistic Support Force, Nanchang, Jiangxi, China.
Purpose:
To assess the discriminatory performance of the platelet-to-thrombin-antithrombin complex ratio (PLT/TAT) for differentiating heatstroke from heat exhaustion and to explore its association with 28-day prognosis and disease severity.
Methods:
This retrospective study analyzed 100 heat illness patients from 2018 to 2025, including 45 with heat exhaustion and 55 with heatstroke. Baseline and admission laboratory data were analyzed using RF, LASSO and SVM-RFE to discern heatstroke risk factors. Diagnostic accuracy of PLT/TAT was evaluated via ROC curve analysis, complemented by Kaplan-Meier and Spearman analyses.
Results:
LASSO, RF, and SVM-RFE analyses identified PLT/TAT, MYO, GCS, Cr, PLT, TAT, PIC, and Lac as heatstroke predictors. The AUC for PLT/TAT in diagnosing heatstroke was 0.938 (95% CI: 0.893-0.982, p < 0.001). At a threshold value of 30.1, the sensitivity and specificity were 86.7% and 89.1%, respectively. Patients with a PLT/TAT ratio below 30.1 exhibited a 5.826-fold increased risk of mortality compared to those with a PLT/TAT ratio above 30.1. Spearman correlation analysis demonstrated a negative correlation between PLT/TAT and Lac (r = -0.519, p < 0.001) and a positive correlation with the GCS score (r = 0.689, p < 0.001), the PLT/TAT ratio exhibited significant negative correlations with ALT (r = -0.614, p < 0.001), AST (r = -0.713, p < 0.001), Cr (r = -0.499, p < 0.001), CK (r = -0.445, p < 0.001) and DIC score(r = -0.764, p < 0.001). The group with PLT/TAT < 30.1 showed significantly elevated Lac levels and reduced GCS score compared to the group with PLT/TAT > 30.1 (p < 0.001).
Conclusion:
The PLT/TAT ratio was associated with heatstroke severity and 28-day survival, making it a promising adjunctive biomarker for diagnosis and risk stratification.
