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Related Experiment Video

Updated: May 26, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Post-Stroke Depression Is Associated With Shared Neurodevelopmental Risk and Circuit Disruption.

Zhi-Jie Xu1,2, Su-Xiang Zhang3, Ji-Ling Li3,4

  • 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Brain and Behavior
|May 25, 2026
PubMed
Summary
This summary is machine-generated.

Post-stroke depression (PSD) involves shared genetic risks and altered brain circuits. This study reveals a unified pathophysiology linking developmental vulnerability to stroke-induced network decompensation, suggesting new therapeutic targets.

Keywords:
default mode networkneurodevelopmentpost‐stroke depressionshared genetic risk

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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

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Last Updated: May 26, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
06:45

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Post-stroke depression (PSD) impacts ~30% of stroke survivors, worsening outcomes.
  • The biological underpinnings of PSD remain largely unknown.

Purpose of the Study:

  • To investigate the genetic and neurobiological basis of post-stroke depression.
  • To identify shared genetic factors and brain circuit alterations in PSD.

Main Methods:

  • Integrated cross-disorder genomics, spatial transcriptomics, and causal neuroimaging.
  • Analyzed genetic overlap using MiXeR and condFDR.
  • Mapped shared risk variants onto the embryonic mouse brain using gsMap.
  • Utilized resting-state fMRI, ICA, FNC, and spDCM to assess brain circuit function.

Main Results:

  • Found significant polygenic overlap between stroke and depression.
  • Identified five pleiotropic loci linked to neuroinflammation and cardio-cerebral signaling.
  • Discovered shared genetic risk enrichment in developing cortical regions.
  • Observed default mode network (DMN)-sensorimotor network (SMN) decoupling and altered auditory network (AN) connectivity in PSD patients.
  • Effective connectivity from AN to DMN correlated with depressive severity.

Conclusions:

  • PSD exhibits a unified pathophysiology combining developmental genetic vulnerability and acquired circuit decompensation.
  • HDAC9/PITX2 pathways and AN-DMN circuitry represent potential therapeutic targets for PSD.
  • Findings support biomarker development and circuit-informed interventions for PSD.