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Updated: May 26, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells

Published on: March 9, 2012

Rap1b Activates Endosomal AC9 to Drive the Second cAMP Wave.

Xuefeng Zhang, Alejandro Pizzoni, Alipio Pinto

    Biorxiv : the Preprint Server for Biology
    |May 25, 2026
    PubMed
    Summary

    Researchers discovered Rap1b activates adenylyl cyclase 9 (AC9), creating a new pathway for cyclic adenosine monophosphate (cAMP) synthesis. This finding explains the previously unclear endosomal cAMP wave, adding spatial regulation to cell signaling.

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