Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally...

Here, we develop a next-generation wireless, battery-free oxygen generating O₂-Macrodevice and wearable power transfer platform that can enable long-term immune protection and subcutaneous function of therapeutic cells. We demonstrate this device supports xenogeneic islet transplantation in C57BL/6J mice evidenced by 90-day diabetes reversal and glucose responsiveness in vivo. We also show partial glycemic control via high-density (>8,000 islets/cm²) human stem-cell derived islets (SC-islets) without immune-suppression in subcutaneous sites for 90 days. Additionally, we confirmed the device supports allogenic islet cell survival and 90-day diabetic reversal in rats. Finally, we demonstrate 1-month islet survival in a nonhuman primate without the need for immune suppression in the subcutaneous space. Collectively, these results indicate the device supports cell survival and function across multiple transplant models in three species without the need for any immunosuppression or external user intervention. These results represent an important set of advances towards immunosuppression free, minimally invasive islet transplantation.