Related Experiment Video

Updated: May 26, 2026

Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

Mammalian, plant, and gut microbiota-derived extracellular vesicles as emerging therapeutics for bone diseases

Guanchen Yin1, Hao Wang1, Yi Liu1

  • 1Department of Bone and Joint Surgery, Orthopaedic Surgery Center, The First Hospital of Jilin University, Changchun, China.

Frontiers in Bioengineering and Biotechnology
|May 25, 2026
PubMed

Insights

Extracellular vesicles (EVs) show promise for treating bone disorders like osteoporosis. This review explores EVs from various sources, especially the gut microbiota, for targeted bone disease therapies.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Bone disorders, including osteoporosis and osteoarthritis, pose significant global health challenges.
  • Current treatments for bone diseases are limited by poor targeting and adverse effects.
  • Extracellular vesicles (EVs) are emerging as biocompatible nanocarriers for intercellular communication and therapy.

Purpose of the Study:

  • To review recent advances in extracellular vesicle (EV)-based therapeutic strategies for bone diseases.
  • To focus on EVs derived from mammalian cells, plants, and gut microbiota.
  • To highlight the therapeutic potential of gut microbiota-derived EVs via the gut-bone axis.

Main Methods:

  • Literature review of recent advancements in EV-based therapies for bone disorders.
  • Comparative analysis of EVs from mammalian cells, plants, and gut microbiota.
  • Evaluation of biological characteristics, advantages, limitations, and applicability of different EV sources.

Main Results:

  • Mammalian, plant, and gut microbiota-derived EVs offer distinct therapeutic advantages for bone diseases.
  • Gut microbiota-derived EVs are increasingly recognized for their role in bone homeostasis through the gut-bone axis.
  • EVs demonstrate potential for improved targeting efficiency and reduced adverse effects compared to conventional therapies.

Conclusions:

  • EVs represent a promising platform for precision therapies in bone disorders.
  • Understanding the unique properties of different EV sources is crucial for rational therapeutic development.
  • Further research into the clinical translation of EVs, particularly those from the gut microbiota, is warranted.
Keywords:
boneextracellular vesiclesgut microbiota-derived extracellular vesiclesmammalian cell-derived extracellular vesiclesplant-derived extracellular vesicles

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