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Related Experiment Video

Updated: May 27, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Pathophysiological mechanisms underlying the overactive bladder.

Neha Sihra1, Sachin Malde2

  • 1Barts and The London NHS Trust, London, UK.

Autonomic Neuroscience : Basic & Clinical
|May 25, 2026
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) is a complex condition with multiple causes. Understanding its varied pathophysiology, including metabolic, hormonal, and neurological factors, is key to developing effective treatments.

Keywords:
Detrusor overactivityMicrobiomeNeurogenic lower urinary tract dysfunctionOveractive bladderPathophysiologyUrgency

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A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
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A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

Related Experiment Videos

Last Updated: May 27, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
06:36

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

Area of Science:

  • Urology
  • Physiology
  • Pathophysiology

Background:

  • Overactive bladder (OAB) presents as a heterogeneous condition with diverse phenotypes.
  • Its complex pathophysiology involves multiple contributing factors, including metabolic syndrome and hormonal changes.

Purpose of the Study:

  • To review the normal physiology of the lower urinary tract.
  • To summarize the key pathophysiological mechanisms underlying overactive bladder.

Main Methods:

  • Literature review of existing studies on lower urinary tract physiology.
  • Synthesis of current understanding of OAB pathophysiology.

Main Results:

  • OAB pathophysiology is multifactorial, involving urotheliogenic, myogenic, neurogenic, and urethrogenic theories.
  • Key contributors include metabolic syndrome, sex hormone deficiency, altered urinary microbiota, gastrointestinal and affective disorders, autonomic dysfunction, and bladder outflow obstruction.

Conclusions:

  • Overactive bladder arises from a complex interplay of physiological and pathological factors.
  • A comprehensive understanding of these mechanisms is essential for targeted therapeutic strategies.