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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

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Prevalence and management of vancomycin non-susceptible Staphylococcus aureus: A narrative review

Aroonlug Lulitanond1, Aroonwadee Chanawong1, Chikara Kaito2

  • 1Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Journal of Infection and Public Health
|May 25, 2026
PubMed

Insights

Vancomycin-nonsusceptible Staphylococcus aureus (VNsSA) is a growing threat, causing treatment failures. This review covers VNsSA prevalence, resistance mechanisms, detection, and management strategies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Staphylococcus aureus is a significant human pathogen causing diverse infections.
  • Antimicrobial resistance is a major challenge in treating S. aureus infections.
  • Vancomycin is a critical antibiotic for Gram-positive bacterial infections, but resistance is emerging.

Purpose of the Study:

  • To review the prevalence of vancomycin-nonsusceptible S. aureus (VNsSA).
  • To summarize mechanisms of vancomycin resistance in S. aureus.
  • To discuss detection methods, clinical challenges, and treatment strategies for VNsSA.

Main Methods:

  • Literature search of PubMed Central (PMC).
  • Review of studies published from 1997 to 2025.
  • Synthesis of information on VNsSA prevalence, resistance, detection, and treatment.

Main Results:

  • Vancomycin resistance in S. aureus is an increasing clinical concern.
  • Multiple mechanisms contribute to vancomycin resistance.
  • Effective detection and management strategies are crucial for VNsSA.

Conclusions:

  • VNsSA poses a significant threat requiring careful attention.
  • Understanding resistance mechanisms and improving detection are key.
  • Current treatment strategies need continuous evaluation and adaptation.
Keywords:
Staphylococcus aureusVISAVRSAVancomycin non-susceptiblehVISA

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