Related Experiment Video
Updated: May 27, 2026

09:50
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Smoking effects on root coverage outcomes between 3 and 12 months: A prospective cohort study.
Hande Has-Elci1,2,3, Duygu Taş4, Zeliha Güney5
1Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
Journal of Periodontology
|May 26, 2026
Summary
Smoking negatively impacts gum graft surgery outcomes, with smokers showing less root coverage a year later. Dentists should consider smoking status for realistic patient expectations.
Area of Science:
- Periodontology
- Regenerative Dentistry
- Oral Health Research
Background:
- Smoking is a known risk factor for periodontal disease.
- Evaluating smoking's impact on root coverage procedures is crucial for treatment planning.
Purpose of the Study:
- To assess the long-term effect of smoking on root coverage outcomes using coronally advanced flap with connective tissue graft (CAF+CTG).
Main Methods:
- Prospective cohort study with 27 participants (smokers and non-smokers).
- Biochemical verification of smoking status (salivary cotinine).
- Clinical parameters assessed at baseline, 3, and 12 months post-surgery.
Main Results:
- Smokers experienced increased recession depth and decreased root coverage percentage at 12 months compared to 3 months.
- Significantly higher root coverage was achieved in non-smokers (87.5%) versus smokers (66.6%) at 12 months (p=0.024).
- Both groups showed increased keratinized tissue width at 12 months, but this did not negate the poorer root coverage in smokers.
Conclusions:
- The detrimental effect of smoking on CAF+CTG outcomes becomes statistically significant at 12 months.
- Smoking status must be considered in treatment planning and patient expectation management for root coverage procedures.
Related Concept Videos
Observational Studies
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
Longitudinal Research
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...