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Updated: May 27, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
[Genetics of primary headache disorders in children and adolescents]
Emilie Davidsen1, Amalie Akulenok Berring-Uldum1, Nanette Mol Debes1,2
1Afdelingen for Børn og Unge, Københavns Universitetshospital - Herlev og Gentofte Hospital.
Abstract:
This review describes current knowledge on the genetics of primary headache disorders in children and adolescents. The heritability for recurrent headache in children and adolescents is estimated at 70%, significantly higher than the heritability for both migraine and tension-type headache in adults. Hemiplegic migraine is a rare monogenic migraine subtype with causal variants identified in CACNA1A, ATP1A2, SCN1A, and PRRT. There is very limited knowledge of genetic risk variants for children and adolescents with polygenic primary headache disorders.
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