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Updated: May 28, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Addressing the influence of unmeasured confounding in observational studies with time-to-event outcomes: a
Linda Amoafo1, Shiyao Xu2, Elizabeth Platz3
1Statistics-Diabetes, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
Abstract:
In this paper, we develop a semiparametric sensitivity analysis approach designed to address unmeasured confounding in observational studies with time-to-event outcomes. We target estimation of the marginal distributions of potential outcomes under competing exposures using influence function-based techniques. We derive the non-parametric influence function for uncensored data and map the uncensored data influence function to the observed data influence function. Our methodology is motivated by and applied to an observational study evaluating the effectiveness of radical prostatectomy (RP) versus external beam radiotherapy with androgen deprivation (EBRT+AD) for the treatment of prostate cancer. We also present a realistic simulation study demonstrating the finite-sample properties of our estimation procedure.
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