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Related Concept Videos

Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Updated: May 28, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Recent advances in cationic material integration for enhanced antimicrobial formulations.

Sara Salatin1, Shirin Ahmadi2,3, Parvin Abedi Ghobadloo4

  • 1Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Drug Development and Industrial Pharmacy
|May 26, 2026
PubMed
Summary

Cationic antimicrobial systems, including surfactants, polymers, peptides, and ionic liquids, show promise against antibiotic-resistant bacteria. These agents offer broad-spectrum activity and reduced resistance potential through membrane disruption.

Keywords:
Cationic antimicrobialsantimicrobial peptideshybrid materialsmembrane disruptionpolymer-based antimicrobialssynergistic formulations

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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

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Last Updated: May 28, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Area of Science:

  • Antimicrobial research
  • Materials science
  • Drug discovery

Background:

  • Cationic antimicrobial compounds offer an alternative to traditional antibiotics.
  • Their membrane-disruptive action, via electrostatic interactions, provides broad-spectrum activity.
  • This mechanism may reduce the development of bacterial resistance.

Purpose of the Study:

  • To review recent advances in cationic antimicrobial systems.
  • To summarize strategies for combating antibiotic-resistant bacteria.

Main Methods:

  • Comprehensive literature review of cationic antimicrobial platforms.
  • Analysis of surfactants, polymers, peptides, quaternary ammonium-based materials, and ionic liquids.
  • Evaluation of emerging strategies against resistant bacteria.

Main Results:

  • Significant progress in enhanced surfactants, advanced cationic polymers, and engineered antimicrobial peptides.
  • Quaternary ammonium-based systems and ionic-liquid antimicrobials show considerable potential.
  • These agents demonstrate efficacy against resistant bacterial strains.

Conclusions:

  • Cationic antimicrobial agents are advancing through diverse chemical designs and formulations.
  • Continued innovation across various systems enhances their promise for clinical and industrial use.
  • These agents represent effective tools against antibiotic-resistant bacteria.