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Related Experiment Video

Updated: May 28, 2026

Large-Scale, Automated Production of Adipose-Derived Stem Cell Spheroids for 3D Bioprinting
07:40

Large-Scale, Automated Production of Adipose-Derived Stem Cell Spheroids for 3D Bioprinting

Published on: March 31, 2022

Nanoparticle-Assembled Stem Cell Building Blocks for Enhanced 3D Adipose Tissue Engineering and Drug Screening.

Laura Ha1,2, Won Hoon Jung1, Kyoung Jin Choi1

  • 1Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea.

ACS Applied Bio Materials
|May 26, 2026
PubMed
Summary

Researchers created advanced 3D adipose spheroids using nanobiohybrids. This novel system improves cell differentiation and reliability for metabolic research and drug discovery.

Keywords:
adipogenic differentiationadipose spheroidsdrug screeninghuman adipose-derived mesenchymal stem cells (hADMSCs)nanobiohybrids

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Last Updated: May 28, 2026

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Published on: March 31, 2022

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Three-Dimensional Cell Culture of Adipose-Derived Stem Cells in a Hydrogel with Photobiomodulation Augmentation
05:42

Three-Dimensional Cell Culture of Adipose-Derived Stem Cells in a Hydrogel with Photobiomodulation Augmentation

Published on: April 5, 2024

Area of Science:

  • Biotechnology
  • Cell Biology
  • Materials Science

Background:

  • Traditional 3D cell cultures present challenges like heterogeneity and poor maturation.
  • These limitations impact their utility in metabolic research and drug discovery.

Purpose of the Study:

  • To engineer a novel 3D adipose spheroid platform using nanobiohybrids.
  • To enhance adipogenic differentiation and reduce heterogeneity in 3D cell cultures.
  • To validate the platform's reliability for pharmacological screening.

Main Methods:

  • Fabrication of nanobiohybrids by attaching mesoporous silica nanoparticles (mSiO2 NPs) to human adipose-derived mesenchymal stem cells (hADMSCs).
  • Formation of 3D adipose spheroids using these nanobiohybrid building blocks.
  • Pharmacological screening using sodium butyrate to assess lipid accumulation and gene expression.

Main Results:

  • Nanobiohybrid spheroids showed enhanced adipogenic differentiation and reduced internal heterogeneity compared to conventional 3D models.
  • Consistent results were observed between in vitro and in vivo evaluations.
  • The system demonstrated high physiological relevance and reliability.

Conclusions:

  • The developed nanobiohybrid-based spheroids offer a superior alternative to traditional 3D culture systems.
  • This platform provides a robust tool for drug screening and therapeutic discovery in metabolic research.
  • The system overcomes limitations of conventional 3D models, enhancing research reliability.