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OSCAR-Assessing Individual Risk Profiles of MRONJ Patients
Felix Pitka1, Florian Böhrnsen1,2
1Clinic for Maxillofacial Surgery, University Medical Center Goettingen, 37075 Goettingen, Germany.
Clinics and Practice
|May 26, 2026
Summary
A new scoring system, OSCAR, helps assess medication-related osteonecrosis of the jaw (MRONJ) severity. Lower scores indicate less severe disease, guiding treatment decisions for MRONJ patients.
Area of Science:
- Oral and Maxillofacial Surgery
- Oncology
- Pharmacology
Background:
- Medication-related osteonecrosis of the jaw (MRONJ) poses a significant clinical challenge.
- Accurate assessment is crucial for effective therapeutic decision-making in MRONJ patients.
Purpose of the Study:
- To develop an individual assessment tool for MRONJ patients.
- To create a scoring system integrating anamnestic, clinical, and radiological data.
- To facilitate therapeutic decisions in MRONJ management.
Main Methods:
- Analyzed clinical data and CT scans from 41 MRONJ patients.
- Developed the Osteonecrosis Scoring Clinical Assessment and Radiological Report (OSCAR) system.
- Correlated OSCAR scores with disease severity and treatment needs.
Main Results:
- OSCAR scores ranged from 4 to 30.
- Lower scores correlated with less severe disease and de-escalated therapy.
- Scores above 15 indicated higher bone density and increased need for surgery (70-71% for Denosumab/bisphosphonate patients).
Conclusions:
- OSCAR scores below 12 suggest a low likelihood of requiring multiple surgical interventions.
- OSCAR parameters are routinely collected, enabling potential AI-assisted assessment.
- The OSCAR system can aid in personalized MRONJ patient assessment and treatment planning.
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