Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Nested Fluid-Structure Interaction Predictive Modeling of Fetal Brain Stress During Maternal Trauma.

Jonathan Mayer1, Molly Bekbolatova1, Timothy Devine2

  • 1Algorithmic Medicine Laboratory, Department of Osteopathic Manipulative Medicine, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, NY 11568, USA.

Biology
|May 26, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and Clinical Patterns of Piriformis Syndrome Among Actively Competing and Retired Elite Hockey Players.

Sports (Basel, Switzerland)·2026
Same author

Editorial for "Predicting Breath Hold Task Compliance From Head Motion".

Journal of magnetic resonance imaging : JMRI·2025
Same author

The Effect of Data Leakage and Feature Selection on Machine Learning Performance for Early Parkinson's Disease Detection.

Bioengineering (Basel, Switzerland)·2025
Same author

Electrocardiogram Abnormality Detection Using Machine Learning on Summary Data and Biometric Features.

Diagnostics (Basel, Switzerland)·2025
Same author

Impact of Convulsive Maternal Seizures on Fetus Dynamics.

International journal for numerical methods in biomedical engineering·2024
Same author

A Safety-Centric Study on the Use of Inflatable Abdominal Binders for Managing Orthostatic Hypotension.

Clinics and practice·2024

Maternal trauma during pregnancy is risky, but the fetus has layered protection. Computational models show amniotic and cerebrospinal fluid systems significantly reduce impact stress on the fetal brain.

Area of Science:

  • Biomedical Engineering
  • Computational Mechanics
  • Fetal Development

Background:

  • Maternal trauma (e.g., accidents, seizures) affects 6-8% of pregnancies, posing risks to fetal development.
  • Existing research often overlooks the integrated protective role of amniotic and cerebrospinal fluids.
  • Previous models treated the fetus as a homogeneous structure, neglecting its nested protective architecture.

Purpose of the Study:

  • To computationally model the integrated protective system of the fetus against mechanical trauma.
  • To analyze the combined cushioning effects of amniotic fluid and cerebrospinal fluid.
  • To investigate the stress distribution and movement of the fetal brain during trauma.

Main Methods:

  • Implemented a nested fluid-structure interaction framework using smoothed particle hydrodynamics and finite element methods.
Keywords:
amniotic fluidcerebrospinal fluidfetal biomechanicsnested fluid–structure interactionprenatal protection

More Related Videos

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
06:56

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Published on: January 7, 2021

Profiling Maternal Behavior Responses During Whole-Brain Imaging
07:12

Profiling Maternal Behavior Responses During Whole-Brain Imaging

Published on: January 24, 2025

Related Experiment Videos

Last Updated: May 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
06:56

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Published on: January 7, 2021

Profiling Maternal Behavior Responses During Whole-Brain Imaging
07:12

Profiling Maternal Behavior Responses During Whole-Brain Imaging

Published on: January 24, 2025

  • Simulated three hierarchical systems: uterine wall-amniotic fluid, amniotic fluid-fetal body, and cranial system (skull, CSF, brain).
  • Utilized experimental data from a medical simulation mannequin subjected to seizure-like forces for boundary conditions.

    • Main Results:

    • Amniotic fluid absorbed most impact forces; cerebrospinal fluid further reduced stress via pressure redistribution, exceeding 90% total reduction.
    • Predicted peak fetal brain stress remained below adult injury thresholds, with minimal fetal brain movement.
    • Elevated stress was noted in the frontal lobe and brainstem, but within potentially tolerable ranges.

    Conclusions:

    • The nested fluid protection architecture acts as an integrated system for sequential energy dissipation.
    • Computational models suggest significant mechanical protection for the fetus during trauma.
    • Findings require experimental and clinical validation before clinical application.