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Altered Lipid Metabolism in Psoriatic Arthritis: A Comprehensive Review
Stanislava Popova-Belova1, Mariela Geneva-Popova1, Stefka Stoilova2
1Department of Propedeutics of Internal Diseases, Faculty of Medicine, Clinic of Rheumatology, University Hospital "Sv. George", Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.
Metabolites
|May 26, 2026
Summary
Psoriatic arthritis (PsA) is linked to abnormal lipid metabolism, increasing cardiovascular disease risk. Managing inflammation and lifestyle factors can improve lipid profiles and patient outcomes.
Area of Science:
- Rheumatology
- Cardiology
- Metabolic Medicine
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting joints and skin.
- PsA patients often experience altered lipid metabolism, elevating cardiovascular disease (CVD) risk.
- Dyslipidemia in PsA is multifactorial, involving inflammation, insulin resistance, and adipokine imbalances.
Purpose of the Study:
- To provide a comprehensive overview of altered lipid metabolism in PsA.
- To explore the mechanisms underlying dyslipidemia in PsA.
- To discuss clinical implications and therapeutic strategies for reducing CVD risk in PsA patients.
Main Methods:
- A structured literature search was performed across PubMed, Scopus, and Web of Science.
- Relevant studies focusing on lipid metabolism in psoriatic arthritis were identified.
- Evidence from selected studies was synthesized using a narrative approach.
Main Results:
- PsA is associated with significant alterations in lipid metabolism, contributing to CVD risk.
- Obesity and metabolic syndrome are common comorbidities that worsen dyslipidemia in PsA.
- Systemic inflammation, insulin resistance, and adipokine dysregulation are key mechanisms.
Conclusions:
- Altered lipid metabolism is a critical concern in psoriatic arthritis management.
- Lifestyle modifications, weight loss, and anti-inflammatory therapies can improve lipid profiles.
- Targeting lipid metabolism is essential for reducing cardiovascular risk in PsA patients.
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