Neural Computing Advancements in Cardiac Imaging: A Review of Deep Learning Approaches for Heart Disease Diagnosis

Heart disease remains a leading cause of mortality worldwide, and timely and accurate diagnosis is crucial for improving patient outcomes. Medical imaging plays a pivotal role in this process, yet traditional diagnostic methods often suffer from limitations, including dependency on manual interpretation, susceptibility to observer variability, and inefficiency in handling large-scale data. Deep learning has emerged as an innovative technology in medical imaging, providing unparalleled advancements in feature extraction, segmentation, classification, and prediction tasks. Despite its proven potential, comprehensive reviews of deep learning methods specifically targeted at cardiac imaging remain scarce. This review paper seeks to bridge this gap by analyzing the state-of-the-art deep learning applications for heart disease diagnosis, covering the period from 2015 to 2025. Employing a well-structured methodology, this review categorizes and examines studies based on imaging modalities: Ultrasound (US), Magnetic Resonance Imaging (MRI), X-ray, Computed Tomography (CT), and Electrocardiography (ECG). For each modality, the analysis focuses on utilized datasets, processing techniques (e.g., extraction, segmentation and classification), and paradigms (e.g., transfer learning, federated learning, explainability, interpretability, and uncertainty quantification). Additionally, the types of heart disease addressed and prediction accuracy metrics are also scrutinized. These findings point toward future opportunities, including the study of data quality, optimization, transfer learning, uncertainty quantification and model explainability or interpretability. Furthermore, exploring advanced techniques such as recurrent expansion, transformers, and other architectures may unlock new pathways in cardiac imaging research. This review is a critical synthesis offering a roadmap for researchers and practitioners to advance the application of deep learning in heart disease diagnosis.