Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glycosaminoglycans

Glycosaminoglycans

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Restoring the powerhouse: mitochondrial transplantation in regenerative medicine and cancer therapy.

Nanoscale·2026

Same author

Review 3D-Printed hydrogels for tissue engineering: a review.

Frontiers in bioengineering and biotechnology·2026

Same author

Wireless Electromagnetic Generation of miRNA Sponges and Nerve Stimulation by an Adaptable Electrical Scaffold for Repair of Traumatic Brain Injury.

ACS nano·2026

Same author

Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery.

Nature communications·2025

Same author

Mechanical performance and aging resistance analysis of zinc oxide-reinforced polyurethane composites.

RSC advances·2025

Same author

Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: May 28, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Hyaluronic Acid-Based Biomaterials in Tissue Engineering: From Molecular Properties to Re-Generative Applications.

Chao-Ming Su¹, Ming-You Shie^2,3, Wan-Ni Huang¹

¹Advanced Therapeutic & Pharmaceutical Center, China Medical University Hospital, Taichung City 40447, Taiwan.

Journal of Functional Biomaterials

|May 26, 2026

Summary

Hyaluronic acid (HA) is a key biomaterial in tissue engineering, regulating cell behavior via receptor interactions. Tailoring HA properties can enhance its use in regenerative medicine and nanomedicine applications.

Keywords:

3D bioprinting HA binding receptor hyaluronic acid hydrogel modification regenerative medicine tissue engineering

More Related Videos

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Published on: May 31, 2018

Synthesis of Decellularized Cartilage Extracellular Matrix Hydrogels

Synthesis of Decellularized Cartilage Extracellular Matrix Hydrogels

Published on: July 21, 2023

Related Experiment Videos

Last Updated: May 28, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Published on: May 31, 2018

Synthesis of Decellularized Cartilage Extracellular Matrix Hydrogels

Synthesis of Decellularized Cartilage Extracellular Matrix Hydrogels

Published on: July 21, 2023

Area of Science:

Biomaterials Science
Tissue Engineering
Extracellular Matrix Biology

Background:

Hyaluronic acid (HA) is a glycosaminoglycan crucial for tissue structure and cellular regulation.
HA's bioactivity is mediated by receptors like CD44 and RHAMM, influenced by its molecular weight and degradation.
Current HA biomaterials offer tunable properties for regenerative medicine but face challenges in clinical translation.

Purpose of the Study:

To review the synthesis, properties, degradation, and signaling of hyaluronic acid (HA).
To establish a mechanistic framework linking HA characteristics to cell responses.
To outline strategies for engineering advanced HA-based biomaterials for improved clinical outcomes.

Main Methods:

Literature review integrating HA synthesis, physicochemical properties, degradation, and receptor signaling.
Mechanistic framework development linking molecular characteristics, matrix mechanics, and cellular responses.
Analysis of design strategies for multifunctional HA composites and biofabrication approaches.

Main Results:

HA's biological outcomes are highly dependent on its molecular weight, degradation, and matrix context.
Advanced chemical modifications enable HA hydrogels, nanofibers, and composites with tunable properties.
A framework is established to guide the rational design of next-generation HA biomaterials.

Conclusions:

Understanding HA's multifaceted roles is essential for optimizing its use in tissue engineering.
Multifunctional HA composites and advanced biofabrication techniques show promise for regenerative medicine.
Targeted engineering of HA-based biomaterials can overcome current limitations and improve clinical translation potential.