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Early Career Perspective: Beyond Quantification: Toward Predicting Regional Emphysema Progression at CT

Cristina Marrocchio1, David A Lynch2

  • 1Unit of Radiological Sciences, Department of Medicine and Surgery, University of Parma, Via Gramsci n.14, 43126 Parma, Italy.

Radiology
|May 26, 2026
PubMed
Summary

No abstract available in PubMed .

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Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.

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