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Updated: May 28, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
Prediction Models for Frailty in People Living With HIV: Protocol for a Systematic Review and Meta-Analysis of
Yeye Hu1, Meilian Xie1,2, Zhiyun Zhang1
1Nursing Management Department, Beijing Ditan Hospital, Capital Medical University, No.8, Jingshun East Street, Chaoyang District, Beijing, 100015, China, 86 13693581102.
This systematic review evaluates frailty prediction models for people living with HIV (PLWH). It identifies robust models and methodological gaps to improve clinical decision-making and guide future research in HIV care.
Area of Science:
- Gerontology
- Infectious Diseases
- Epidemiology
Background:
- Antiretroviral therapy has increased HIV life expectancy, leading to higher frailty prevalence.
- Existing frailty models may not suit people living with HIV due to unique health profiles.
- No comprehensive review exists for frailty prediction models in people living with HIV.
Purpose of the Study:
- Identify and appraise frailty prediction models for people living with HIV.
- Critically evaluate the methodological quality of these models.
- Summarize their predictive performance.
Main Methods:
- Systematic literature search of major databases (PubMed, Web of Science).
- Screening and data extraction by two independent reviewers using CHARMS and TRIPOD.
- Risk of bias and applicability assessment using PROBAST; meta-analysis if appropriate.
Main Results:
- Protocol registered with PROSPERO (CRD420261332573).
- Literature search conducted July 20, 2025; five studies identified by October 2025.
- Data analysis planned for April 2026; manuscript submission by June 2026.
Conclusions:
- This review offers the first comprehensive synthesis of frailty prediction models for people living with HIV.
- Findings will identify robust models and highlight methodological gaps.
- Expected to inform clinical practice and future model development in HIV care.
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