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Chambers of the Heart01:16

Chambers of the Heart

The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...

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Related Experiment Video

Updated: May 28, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

Patent Foramen Ovale and Atrial Septal Defect.

Joe Aoun1, Taha Hatab1, John Volpi2

  • 1Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.

Cardiac Electrophysiology Clinics
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Patent foramen ovale (PFO) and atrial septal defects (ASDs) are heart conditions that can lead to serious complications like stroke. Early diagnosis and proper management are crucial for preventing risks and improving patient outcomes.

Keywords:
Atrial septal defectEchocardiographyPatent foramen ovaleTranscatheter closure

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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

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Last Updated: May 28, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
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Published on: June 15, 2015

Area of Science:

  • Cardiology
  • Congenital Heart Disease

Background:

  • Patent foramen ovale (PFO) and atrial septal defects (ASDs) are common interatrial communications.
  • PFO persists in 25-30% of adults, potentially causing paradoxical embolism and stroke.
  • ASDs often lead to right heart volume overload and can be associated with other congenital defects.

Purpose of the Study:

  • To differentiate PFO and ASDs based on clinical presentation and management.
  • To describe diagnostic methods, treatment options, and potential complications for PFO and ASDs.
  • To emphasize the importance of accurate diagnosis and timely intervention.

Main Methods:

  • Review of diagnostic modalities for PFO and ASDs.
  • Analysis of treatment strategies, including surgical and percutaneous interventions.
  • Evaluation of potential complications associated with both conditions.

Main Results:

  • PFO may lead to embolic stroke due to paradoxical embolism.
  • ASDs typically cause right heart volume overload.
  • Both conditions require precise diagnosis and tailored management.

Conclusions:

  • Accurate diagnosis and appropriate management are essential for PFO and ASDs.
  • Interventions aim to mitigate risks such as stroke and heart failure.
  • Optimizing patient outcomes depends on a comprehensive approach to these cardiac conditions.