Non-surgical management of mandibular central giant cell granuloma using denosumab
Shivanjali Pandya1, Megan Samuel2, Janavikulum Thiruchelvam2
1Barts and the London School of Medicine and Dentistry, Queen Mary University of London, England, E1 2AD, United Kingdom; Department of Oral and Maxillofacial Surgery, Broomfield Hospital, Mid and South Essex NHS Foundation Trust, Chelmsford, England, CM1 7ET, United Kingdom.
Abstract:
The typical management of central giant cell granuloma (CGCG) of the jaws involves curettage or resection; however, in selected cases, medical therapies such as denosumab have emerged as potential alternatives. We present the case of a 22-year-old patient who presented with a right mandibular expansile lesion. Imaging and biopsy confirmed mandibular CGCG. The patient was managed non-surgically with denosumab, and follow-up imaging demonstrated lesion stabilisation and radiographic maturation. Denosumab may represent an alternative to surgery when operative management carries significant morbidity.
