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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Related Experiment Video

Updated: May 28, 2026

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
05:45

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Published on: April 5, 2019

Serum MAP1A as a Potential Biomarker for Autism Spectrum Disorder.

Jiwon Jeong1, Seung Hyeon Lee1, Dongsun Park1

  • 1Laboratory of Veterinary Toxicology, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.

Brain Sciences
|May 27, 2026
PubMed
Summary

Researchers identified MAP1A as a potential blood biomarker for autism spectrum disorder (ASD). Elevated serum MAP1A levels in a rat model suggest its role in synaptic abnormalities associated with ASD.

Keywords:
MAP1ARNA sequencingautism spectrum disorderserum biomarkersynaptic genesvalproic acid model

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Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Related Experiment Videos

Last Updated: May 28, 2026

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
05:45

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Published on: April 5, 2019

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Genetics

Background:

  • Autism spectrum disorder (ASD) diagnosis relies on subjective behavioral assessments.
  • Objective blood-based biomarkers are needed for earlier and more accurate ASD identification.
  • This study focuses on identifying synapse-related biomarkers for ASD.

Purpose of the Study:

  • To identify synapse-related biomarkers associated with ASD.
  • To evaluate the potential of these biomarkers as serum-based indicators.
  • To investigate synaptic abnormalities in an ASD rat model.

Main Methods:

  • RNA sequencing in cerebellum, hippocampus, and cortex of a valproic acid-induced ASD rat model.
  • Functional enrichment analyses (GO, KEGG) to identify affected pathways.
  • Selection of synapse-related hub genes and assessment of serum protein expression via Western blotting.

Main Results:

  • Identified 692, 813, and 1059 differentially expressed genes in cerebellum, hippocampus, and cortex, respectively.
  • Enrichment analyses revealed significant involvement of dendrite development, postsynaptic density, and glutamatergic synapse pathways.
  • Serum MAP1A expression was significantly elevated in ASD rats among prioritized synaptic hub genes.

Conclusions:

  • Serum MAP1A may serve as a potential biomarker for synaptic abnormalities in ASD.
  • Further validation in human cohorts is necessary.
  • Integration into a multi-marker framework is recommended to address ASD heterogeneity.