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Updated: May 28, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Effect Modification of Alcohol Use on Epilepsy: NHIS Longitudinal Study.

Sri Banerjee1, W Sumner Davis1, Kay Banerjee1,2

  • 1College of Health Sciences and Public Policy, Walden University, Minneapolis, MN 55401, USA.

Biomedicines
|May 27, 2026
PubMed
Summary

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This summary is machine-generated.

Epilepsy combined with alcohol use significantly increases mortality risk. This risk is higher for Black individuals, highlighting the need for tailored care and further research into influencing factors.

Area of Science:

  • Neurology
  • Public Health
  • Epidemiology

Background:

  • Alcohol's complex relationship with epilepsy includes lowering seizure thresholds and potential epileptogenesis.
  • Chronic alcohol misuse can lead to neuronal injury and neurotransmitter dysregulation.
  • The long-term mortality impact of alcohol use in people with epilepsy (PWE) is not well understood.

Purpose of the Study:

  • To evaluate all-cause mortality risk in individuals with epilepsy based on alcohol consumption.
  • To stratify mortality risk by race/ethnicity in the context of epilepsy and alcohol use.

Main Methods:

  • Utilized data from the 2008-2018 National Health Interview Survey (NHIS) linked to the National Death Index (NDI).
  • Included U.S. adults aged 18+; PWE and alcohol use determined via self-report.
Keywords:
alcohol abusealcohol withdrawal seizuresantiseizure medicationcomorbidityepilepsyneurobiology

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  • Employed Kaplan-Meier survival analysis and adjusted Cox proportional hazards models.

    • Main Results:

    • Alcohol use among PWE was linked to increased all-cause mortality (adjusted HR=1.40).
    • Alcohol use without epilepsy did not show elevated mortality risk after adjustment.
    • The epilepsy-alcohol combination significantly increased mortality in Black individuals, but not White individuals.

    Conclusions:

    • Combined epilepsy and alcohol use is associated with higher all-cause mortality than alcohol use alone.
    • Observed racial disparities in mortality risk necessitate further investigation.
    • Integrated clinical care and research into genetic, biological, and social determinants are crucial for improving epilepsy outcomes.