Prognostic Impact of ABO/Rh Blood Group-Systemic Inflammation Indices Interactions in Small-Cell Lung Cancer
Anıl Yıldız1, Burak Alper Zengin2, Maral Martin Mildanoglu3
1Department of Medical Oncology, Basaksehir Cam ve Sakura City Hospital, 34480 İstanbul, Türkiye.
Biomedicines
|May 27, 2026
Summary
Small-cell lung cancer patients with non-O blood groups and high systemic inflammation response index (SIRI) show worse treatment response and survival. Host biology, like blood type, influences inflammation
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- ABO/Rh blood groups and systemic inflammation are individually linked to cancer prognosis.
- Their combined prognostic value in small-cell lung cancer (SCLC) remains unclear.
Purpose of the Study:
- To investigate ABO/Rh blood group distribution in SCLC patients.
- To assess associations between blood groups and inflammatory markers.
- To determine the prognostic significance of blood group-inflammation interactions on treatment response and survival.
Main Methods:
- Retrospective study of 158 SCLC patients with ABO/Rh typing and CBC data.
- Calculation of inflammatory indices: Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Systemic immune-inflammation index (SII), and Systemic inflammation response index (SIRI).
- Analysis of treatment response (RECIST v1.1) and survival outcomes (PFS, OS) using Cox regression with interaction terms.
Main Results:
- Blood group O associated with lower baseline inflammatory indices.
- Non-O blood groups and higher SIRI independently predicted treatment non-response and increased risks of progression and mortality.
- SIRI showed superior diagnostic performance over SII, NLR, and PLR.
- Highest risks of progression and mortality observed in patients with blood group AB and high SIRI.
Conclusions:
- ABO blood group influences SCLC inflammatory profiles.
- Elevated SIRI is an independent predictor of poor treatment response and survival in SCLC.
- The prognostic impact of SIRI is modulated by ABO blood group, highlighting host biology's role in systemic inflammation.
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