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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Related Experiment Video

Updated: May 28, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
10:33

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

Cryopreserved Mucosal Olfactory Ensheathing Cells Promote Functional Recovery After Dorsal Root Injury.

Kamile Minkelyte1, Daqing Li1, Ying Li1

  • 1Spinal Repair Unit, Department of Translational Neuroscience and Stroke, UCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

Cells
|May 27, 2026
PubMed
Summary

Cryopreservation maintains the therapeutic potential of olfactory ensheathing cells (OECs) for spinal cord repair. Cryopreserved OECs (CmOECs) promote axonal regeneration and functional recovery in rats, supporting biobank development.

Keywords:
cryopreservationneuroregenerationolfactory ensheathing cellsspinal cord injurytransplantation

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Isolating Nasal Olfactory Stem Cells from Rodents or Humans
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Isolating Nasal Olfactory Stem Cells from Rodents or Humans

Published on: August 22, 2011

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Last Updated: May 28, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
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Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
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Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

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Isolating Nasal Olfactory Stem Cells from Rodents or Humans
09:19

Isolating Nasal Olfactory Stem Cells from Rodents or Humans

Published on: August 22, 2011

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Olfactory ensheathing cell (OEC) transplantation aids central nervous system (CNS) repair.
  • Autologous OEC therapy faces limitations due to low cell yields from biopsies, insufficient for extensive spinal cord injuries.
  • Scalable OEC sources are needed for effective spinal cord repair strategies.

Purpose of the Study:

  • To evaluate cryopreservation's ability to preserve the therapeutic potential of mucosa-derived OECs.
  • To assess the viability, phenotype, and efficacy of cryopreserved mucosa-derived OECs (CmOECs) in a rat dorsal root injury model.
  • To determine if CmOECs can support axonal regeneration and functional recovery comparable to primary OECs.

Main Methods:

  • Mucosa-derived OECs were cryopreserved and thawed.
  • CmOECs were assessed for viability, morphology, and marker expression in vitro.
  • Transplantation of CmOECs into a rat dorsal root injury model was performed, followed by functional and immunohistochemical analyses.

Main Results:

  • Cryopreservation reduced total viable cell yield but maintained OEC proportion and phenotype in vitro.
  • Transplantation of CmOECs led to significant functional recovery in climbing and forepaw tasks.
  • Immunohistochemistry confirmed CmOEC survival, integration, axonal regeneration, and astrocytic remodeling in vivo.
  • Functional recovery with CmOECs was comparable to primary OEC transplantation.

Conclusions:

  • Mucosa-derived OECs retain therapeutic efficacy after cryopreservation.
  • Cryopreservation offers a scalable method for OEC banking for spinal cord repair.
  • Standardized OEC biobanks are a viable strategy for advancing spinal cord injury treatments.