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Updated: May 28, 2026
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Metastatic Patterns and Adverse Histopathologic Features in Advanced Renal Cell Carcinoma: A Five-Year Single-Center
Adelina Vidac1, Alis Dema1,2, Robert Barna1
1ANAPATMOL Research Center, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Medicina (Kaunas, Lithuania)
|May 27, 2026
Summary
This study analyzed metastatic renal cell carcinoma (RCC) cases, finding brain and bone as common sites. Aggressive features were frequent, though specific links to metastasis patterns require more research.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Renal cell carcinoma (RCC) has unpredictable metastatic behavior.
- Institutional analysis of metastatic RCC aids diagnostic recognition.
Purpose of the Study:
- To characterize metastatic distribution and histopathologic features of RCC.
- To identify common and uncommon metastatic sites in a single tertiary center.
Main Methods:
- Retrospective review of pathology database (2020-2024).
- Identified histologically confirmed metastatic RCC cases.
- Collected histopathological data: WHO/ISUP grade, necrosis, differentiation, invasion, margins, size, pT stage.
Main Results:
- 32 clear cell RCC cases identified; mean age 62.9, male predominance.
- Common sites: brain, bone, adrenal gland, lymph nodes, liver.
- Brain metastases associated with high-grade tumors; high tumor necrosis prevalence observed.
Conclusions:
- RCC exhibits a broad metastatic spectrum, including rare sites.
- Clear cell morphology and adverse features link to aggressive biology.
- Observed patterns suggest potential metastasis-site/tumor-characteristic relationships needing further study.
