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Updated: May 28, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Acoustic Streaming-Based 3D Cell Focusing and Plasma Separation.

Jingjing Zheng¹, Qian Wu², Zhenheng Lin¹

¹College of Artificial Intelligence, Putian Electronic Information Industry Technology Research Institute, Putian University, Putian 351100, China.

|May 27, 2026

Summary

This summary is machine-generated.

This study introduces a novel acoustofluidic platform for efficient plasma separation from blood. The sheath-free microchip device uses acoustic streaming to concentrate cells, enabling rapid, high-purity plasma extraction for point-of-care testing.

Keywords:

acoustofluidics cell focusing integrated microfluidic plasma separation

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Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator

Published on: May 14, 2020

Area of Science:

Biomedical Engineering
Microfluidics
Acoustofluidics

Background:

Plasma separation is crucial for point-of-care diagnostics but often requires complex microfluidic methods.
Existing techniques may involve intricate sample pretreatment or multi-step processes.

Purpose of the Study:

To develop an integrated, sheath-free acoustofluidic platform for efficient plasma extraction from small blood volumes.
To demonstrate a novel method for three-dimensional (3D) cell focusing and plasma separation using acoustic streaming.

Main Methods:

An integrated microchip device utilizing symmetric cavity-trapped bubbles to generate acoustic streaming.
Acoustic excitation to reconstruct flow fields and drive cells to a central outlet, separating plasma into side outlets.
Operation adjusted via acoustic-voltage control for varying inflow conditions.

Main Results:

Achieved approximately 71% plasma recovery and 99% plasma purity with simulated blood samples.
Demonstrated good biocompatibility with high cell viability under tested conditions.
The platform is operable across a range of inflow rates through acoustic-voltage adjustment.

Conclusions:

The developed acoustofluidic platform offers a simple, integrated, and sheath-free solution for plasma separation.
This technology shows significant potential for miniaturized sample preparation in point-of-care applications.
Further validation with whole blood and clinical plasma metrics is necessary for future development.