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PSPH and CXCL2 Predict Treatment Response in First-Episode Schizophrenia: a Retrospective Study.
Clinical Laboratory
|May 20, 2026
Summary
Serum levels of Phosphoserine Phosphatase (PSPH) and Chemokine C-X-C Motif Ligand 2 (CXCL2) show promise as biomarkers. Elevated levels predict poor antipsychotic treatment response in male first-episode schizophrenia patients.
Area of Science:
- Neuroscience
- Biomarker Discovery
- Psychiatry
Background:
- Schizophrenia treatment response prediction remains challenging.
- Identifying reliable biomarkers is crucial for personalized medicine.
Purpose of the Study:
- To evaluate serum Phosphoserine Phosphatase (PSPH) and Chemokine C-X-C Motif Ligand 2 (CXCL2) levels.
- To assess their potential as predictive biomarkers for antipsychotic treatment efficacy.
- Focus on male first-episode schizophrenia patients.
Main Methods:
- Retrospective analysis of 297 male patients treated with olanzapine.
- Serum PSPH and CXCL2 levels measured by ELISA.
- Receiver Operating Characteristic (ROC) and logistic regression analyses performed.
Main Results:
- Non-improvement group showed significantly higher serum PSPH and CXCL2 levels.
- Both biomarkers positively correlated with Positive and Negative Syndrome Scale (PANSS) scores.
- Combined PSPH and CXCL2 levels demonstrated a high predictive performance (AUC = 0.823).
Conclusions:
- Serum PSPH and CXCL2 levels are potential predictive biomarkers for antipsychotic treatment response.
- These biomarkers may aid in optimizing treatment strategies for schizophrenia.
- Further validation in diverse patient populations is warranted.
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