Plasma-Derived Exosomal circGAPVD1 Predicts Malignant Bowel Obstruction in Colorectal Cancer

Area of Science:

• Oncology
• Gastroenterology
• Biomarker Discovery

Background:

• Colorectal cancer (CRC) patients are at risk of postoperative malignant bowel obstruction (MBO).
• Early prediction of MBO is crucial for timely intervention and improved patient outcomes.
• Identifying reliable predictive markers for MBO in CRC is an ongoing clinical challenge.

Purpose of the Study:

• To evaluate the predictive capability of specific hematological parameters and plasma-derived exosomal circGAPVD1 for MBO.
• To assess the combined diagnostic accuracy of these markers in predicting MBO post-CRC surgery.
• To identify independent risk factors for MBO development in colorectal cancer patients.

Main Methods:

• A cohort of 120 colorectal cancer patients undergoing surgery was analyzed.
• Patients were categorized into MBO (n=20) and non-MBO (n=100) groups one week post-surgery.
• Logistic regression was employed to analyze risk factors and the predictive value of selected hematological parameters (NE, RDW, NLR, PLR) and circGAPVD1.

Main Results:

• Elevated levels of WBC, NE, LY, RBC, HGB, RDW, PLT, NLR, PLR, and circGAPVD1 were observed post-surgery.
• MBO patients showed a higher incidence of rectal tumors and clinical stage III, with fewer laparoscopic surgeries.
• NE, RDW, NLR, and PLR were identified as independent risk factors for MBO; combined testing with circGAPVD1 significantly improved AUC values.

Conclusions:

• Plasma-derived exosomal circGAPVD1 and specific hematological markers (NE, RDW, NLR, PLR) demonstrate significant predictive value for MBO in CRC.
• The combination of these markers substantially enhances the accuracy of MBO prediction compared to individual tests.
• This multimodal approach offers a promising strategy for early MBO detection in postoperative CRC patients.