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Magnapen treatment of infections in the elderly

R S Middleton, H K Sinha

    The Journal of International Medical Research
    |January 1, 1979
    PubMed

    Insights

    Magnapen, a penicillin combination, effectively treats infections, especially in the elderly. Clinical studies show high cure rates and minimal side effects, validating its practical use.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Semi-synthetic penicillins offer broad-spectrum activity, good bioavailability, and a low incidence of side effects.
    • Magnapen combines two such penicillins, theoretically enhancing therapeutic advantages.
    • The elderly population often presents complex infections, making effective treatment crucial.

    Purpose of the Study:

    • To evaluate the clinical efficacy and safety of Magnapen syrup in treating infections.
    • To assess the practical benefits of Magnapen in a patient population with specific challenges.
    • To confirm theoretical advantages of the penicillin combination in real-world application.

    Main Methods:

    • A study involving 96 patients treated with Magnapen syrup.
    • Assessment of clinical cure rates, improvement, and failure.
    • Bacteriological evaluation of infecting organisms' clearance.
    • Monitoring and recording of adverse events.

    Main Results:

    • 73% of patients achieved clinical cure, with an additional 19% showing improvement.
    • Clinical failure was observed in 8% of patients.
    • Bacteriological clearance was achieved in 90% (47/52) of assessable patients.
    • Side effects were reported in 4% (4/96) of patients, with one discontinuation.

    Conclusions:

    • Magnapen demonstrates significant clinical efficacy and a favorable safety profile in treating infections.
    • The study validates the practical utility of Magnapen, particularly for infections in the elderly.
    • The combination therapy is effective in eradicating infecting organisms with a low incidence of adverse events.

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