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Anti-hypertensive therapy in the elderly and its effects on cerebral function
Mechanisms of Ageing and Development
|December 1, 1984
Summary
Moducren effectively lowers blood pressure in elderly hypertensive patients without significant side effects. Cerebral function, plasma potassium, and blood urea levels remained unaffected during the study.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Clinical Pharmacology
Background:
- Hypertension is a prevalent condition in the elderly population.
- Effective and safe antihypertensive treatments are crucial for this demographic.
- Moducren is a potential therapeutic agent for managing hypertension.
Purpose of the Study:
- To evaluate the efficacy and safety of Moducren in elderly hypertensive patients.
- To assess the impact of Moducren on blood pressure and potential side effects.
- To investigate the effects of Moducren on cerebral function, plasma potassium, and blood urea.
Main Methods:
- A double-blind, crossover study design was employed.
- Seventeen elderly hypertensive patients (67-86 years) participated.
- Psychometric testing using the Clifton Assessment Procedure for the Elderly was conducted over 18 weeks.
Main Results:
- Moducren demonstrated significant blood pressure reduction in elderly hypertensives.
- The incidence of side effects associated with Moducren was not high.
- Plasma potassium, blood urea, and cerebral function were not adversely affected by Moducren treatment.
Conclusions:
- Moducren is an effective antihypertensive medication for elderly patients.
- The drug exhibits a favorable safety profile with minimal impact on key physiological markers.
- Moducren represents a promising option for managing hypertension in the elderly.
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