Platelet-Rich Plasma-Derived Exosome Olfactory Cleft Injection for Treating Traumatic Olfactory Dysfunction

Background: Recently, platelet-rich plasma (PRP) nasal injections have been used to treat traumatic olfactory dysfunction related to Coronavirus disease 2019. Currently, however, platelet-rich plasma-derived exosomes (PREs) are emerging as key effectors of PRP activity and, when compared with PRP, exhibit superior stability and minimal immunogenicity. Case Presentation: We described a case of a 27-year-old woman who lost her olfactory function after hitting her head on 8 July 2022. A smell test demonstrated complete loss of olfactory function. She performed olfactory training and received PRP olfactory cleft injections three times, allowing her olfactory function to gain mild improvement. Subsequently, she received four additional PRE olfactory cleft injections, allowing her olfactory function to improve even further. Conclusions: This study presents a case of traumatic olfactory dysfunction treated with PRE olfactory cleft injections, but no real conclusions can be drawn regarding the efficacy of PRE olfactory cleft injection on traumatic olfactory dysfunction by a single case report.