Subject-Wise Depression Screening from Eight-Channel Resting-State EEG Using Asymmetry-Aware Spectral Features and...

Major depressive disorder remains difficult to diagnose objectively, as routine assessment is still largely dependent on clinical interview and rating scales. Resting-state electroencephalography (EEG) is an attractive complementary modality because it is non-invasive, low-cost, and compatible with wearable sensing, but many reported EEG classification results are weakened by segment-level leakage and unclear subject identity handling. This study evaluates whether depression can be distinguished from healthy controls using a compact eight-channel resting-state EEG configuration under a strictly leakage-free subject-wise protocol. Using a widely used public EEG dataset, we first corrected a previously overlooked subject-identity ambiguity by constructing a class-aware composite key, yielding 56 valid unique participants. We then applied ten repeated subject-wise holdout splits and compared five compact baselines spanning Extra Trees and a multi-layer perceptron on asymmetry-aware spectral features and three convolutional networks on raw signals, including the EEG-specific EEGNet and ShallowConvNet architectures. Uncertainty was quantified through 95% bootstrap confidence intervals of the mean across repeats. The best model, an Extra Trees classifier using eight-channel spectral and asymmetry features, achieved a mean balanced accuracy of 93.5% with a 95% bootstrap confidence interval of 89.6% to 96.8% and a mean area under the receiver operating characteristic curve of 98.6% with a 95% bootstrap confidence interval of 96.2% to 100.0%. A connectivity ablation showed that inter-channel coherence was informative in isolation but did not improve performance when naively fused with spectral features. A feature-selection ablation did not show evidence that the 90-dimensional spectral representation was dominated by noisy or uninformative dimensions under this evaluation protocol. These results support compact, subject-wise evaluated EEG screening pipelines while highlighting the importance of rigorous leakage control.