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Updated: May 28, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Cellulose Acetate/Hydroxyapatite-Dexamethasone Loaded Membranes for the Prevention of Implant-Associated Acute
Stefan Ioan Voicu1,2,3, Andreea Madalina Pandele1,2, Adrian Ionut Nicoara4
1Department of Analytical Chemistry and Environmental Engineering, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gheorghe Polizu, 011061 Bucharest, Romania.
Abstract:
Implant-associated acute inflammation remains a major challenge in orthopedic, dental, and maxillofacial applications, often impairing osseointegration and leading to early implant failure. In this study, multifunctional cellulose acetate/hydroxyapatite-dexamethasone (CA/HA-DEXA) composite membranes were developed to locally modulate inflammation while supporting early bone-implant interactions. Cellulose acetate provides a flexible matrix, hydroxyapatite enhances bioactivity and osteoconductivity, and dexamethasone acts as an anti-inflammatory agent. The membranes exhibited composition-dependent swelling and drug release behavior. The swelling degree decreased from ~11% for pristine CA to ~5% for the highest HA-DEXA loading, indicating a denser structure with restricted water uptake. Dexamethasone release showed a biphasic profile, with cumulative release reaching ~68%, ~88%, and ~93% for 0.5%, 1%, and 2% HA-DEXA loadings after 72 h, respectively. In vitro evaluation indicated improved biomineralization for CA/HA-DEXA membranes compared to neat CA, attributed to the role of hydroxyapatite as a nucleation promoter. These findings suggest that CA/HA-DEXA composite membranes represent a promising strategy for controlling early inflammatory responses while supporting bone regeneration at the implant interface.
