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Related Experiment Video

Updated: May 28, 2026

Human Cartilage Tissue Fabrication Using Three-dimensional Inkjet Printing Technology
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Published on: June 10, 2014

Multi-Component 3D Bioprinted Platform with Sacrificial Matrix and Collagen-Based Bioinks for Skeletal Muscle Tissue

Carmen Mª Granados-Carrera1, Francisco José Calero Castro2,3, Victor M Perez-Puyana4

  • 1Departamento de Ingeniería Química, Facultad de Química, Universidad de Sevilla, 41012 Sevilla, Spain.

Polymers
|May 27, 2026
PubMed
Summary

This study presents a 3D bioprinted platform for skeletal muscle tissue engineering, using polycaprolactone and gelatin with collagen-based bioinks. Extracellular matrix bioinks show promise for creating functional muscle constructs with enhanced cell viability.

Keywords:
3D bioprintingbiofabricationcollagen-based bioinksextracellular matrixrheologyscaffoldsskeletal muscle tissue engineering

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Published on: January 3, 2018

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Skeletal muscle tissue engineering faces challenges in creating functional, biomimetic constructs.
  • Mechanical stimulation and appropriate biomaterials are crucial for engineered muscle development.

Purpose of the Study:

  • To develop and evaluate a multi-component 3D bioprinted platform for skeletal muscle tissue engineering.
  • To investigate the influence of polycaprolactone architecture, gelatin concentration, and bioink composition on construct properties.

Main Methods:

  • Fabrication of a 3D bioprinted platform using polycaprolactone (PCL) support, sacrificial gelatin (GE) matrix, and collagen-based bioinks.
  • Systematic evaluation of PCL architecture, GE concentration (0.75-3 wt%), and bioink formulations (collagen, collagen-Matrigel, ECM-based).
  • Characterization using rheology, microstructural analysis, and assessment of cell viability and structural organization.

Main Results:

  • All bioinks exhibited shear-thinning behavior and suitable viscoelastic properties for bioprinting.
  • The PCL/GE platform demonstrated mechanical stability for bioreactor conditions.
  • ECM-based bioinks resulted in highly interconnected porous networks, highest cell viability, and improved structural organization.

Conclusions:

  • A versatile 3D bioprinting strategy combining mechanical support and biomimetic environments was demonstrated.
  • The developed platform shows potential for fabricating functional skeletal muscle constructs.
  • Extracellular matrix-based bioinks are promising for advanced skeletal muscle tissue engineering applications.