Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial Resistance in Pediatric Infections: Current Status, Challenges, and Future Directions.

Antibiotics (Basel, Switzerland)·2026
Same author

Microbiome-Responsive Hydrogels: From Biological Cues to Smart Biomaterials.

Pharmaceutics·2026
Same author

Gadolinium Nanoparticles: Emerging Platforms Beyond Imaging for Drug Delivery and Theranostics.

Pharmaceutics·2026
Same author

Selectivity Modulation of Small Cationic Membrane-Active Cyclic Peptides with Broad-Spectrum Activity against Bacteria and Fungi.

Journal of medicinal chemistry·2026
Same author

Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles.

Drug design, development and therapy·2026
Same author

Fatty Acid-Conjugated Antimicrobial Peptides: Advances in Design, Activity, and Therapeutic Potential.

Journal of medicinal chemistry·2026
Same journal

Correction: Jiménez-Sánchez et al. Antioxidant Enzymes Genetic Variants Associated with Urticaria/Angioedema Induced by Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs. <i>Pharmaceuticals</i> 2026, <i>19</i>, 522.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Correction: Zhao et al. Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing. <i>Pharmaceuticals</i> 2022, <i>15</i>, 750.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Intravenous Immunoglobulin Reveals a Novel Protective Mechanism: Targeting the GBP5-Driven Pyroptosis Axis in Experimental Colitis.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Icariin Attenuates Renal Injury in Streptozotocin-Induced Diabetic Rats with and Without Adenine-Induced Chronic Kidney Disease.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

AI-Assisted Identification of a Putative Allosteric Ligand Targeting the CDK4/Cyclin D1 Protein-Protein Interface.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Development and Study of Hydrophilic Ointment Compositions with a Dextrin/Polyvinyl Alcohol/Iodine Complex (D/PVA/I).

Pharmaceuticals (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: May 28, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

Iron-Based Nanoparticles as Delivery Tools.

Keykavous Parang1, Rajesh Vadlapatla2, Ajoy Koomer2

  • 1Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Rd., Irvine, CA 92618, USA.

Pharmaceuticals (Basel, Switzerland)
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Iron oxide nanoparticles (IONPs) offer versatile drug delivery and theranostic solutions. Surface modifications enhance their stability and targeting for advanced nanomedicine applications, though clinical translation requires addressing safety and reproducibility.

Keywords:
Fe3O4Fe3O4@SiO2SPIONsdrug deliveryiron oxide nanoparticlesmagnetic nanoparticlesγ-Fe2O3

More Related Videos

Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Related Experiment Videos

Last Updated: May 28, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
09:36

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Area of Science:

  • Nanomedicine and Biomedical Engineering
  • Materials Science and Chemistry

Background:

  • Iron oxide nanostructures (IONPs), especially superparamagnetic iron oxide nanoparticles (SPIONs), are promising for medical applications due to their biocompatibility and magnetic properties.
  • SPIONs enable targeted drug delivery, enhanced MRI contrast, and hyperthermia for combined diagnosis and therapy.

Purpose of the Study:

  • To review the physicochemical properties, synthesis, and surface engineering of iron-based nanoparticles.
  • To highlight their biomedical applications, focusing on advanced multifunctional and peptide-functionalized systems.
  • To discuss challenges and future perspectives for clinical translation in precision nanomedicine.

Main Methods:

  • Review of existing literature on iron-based nanoparticles.
  • Analysis of synthesis strategies and surface functionalization techniques.
  • Evaluation of drug-loading mechanisms and theranostic applications.

Main Results:

  • Surface functionalization improves stability, circulation, targeting, and drug release of IONPs.
  • Hybrid systems integrate multiple therapies like chemotherapy, gene delivery, and photothermal therapy.
  • Preclinical studies show significant potential, but challenges in biosafety and reproducibility persist.

Conclusions:

  • Iron-based nanoparticles, particularly SPIONs, are highly versatile for theranostics and drug delivery.
  • Continued research into multifunctional systems and addressing translational challenges is crucial for clinical success.
  • Advances in peptide functionalization and hybrid systems pave the way for precision nanomedicine.