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Primary Signet Ring Cell Carcinoma Bilateral Breast: An Exceptional Occurrence
Garima Dhull1, Mukta Pujani1, Varsha Chauhan1
1Dept. of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India.
Iranian Journal of Pathology
|May 27, 2026
Summary
Signet ring cell carcinoma (SRCC) of the breast is rare and aggressive. Differentiating primary breast SRCC from other cancers, especially in bilateral cases, is crucial for accurate diagnosis and treatment.
Area of Science:
- Oncology
- Pathology
Background:
- Signet ring cell carcinoma (SRCC) of the breast is an exceptionally rare subtype, comprising 0.04% to 2.7% of all breast cancers.
- Pure SRCC (>90% signet ring cells) presents an aggressive clinical profile, often with high histologic grade, lympho-vascular invasion, hormone receptor positivity, and low HER2 expression.
