Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Vibration Anesthesia on Injection-Related Pain: A Prospective Crossover Study [Response to Letter].

Journal of pain research·2026
Same author

Clinical Pharmacology of Plozasiran.

American journal of cardiovascular drugs : drugs, devices, and other interventions·2026
Same author

Non-Interventional Study to Evaluate the Effect of Non-Diffractive Extended Depth of Focus Intraocular Lens Centration and Tilt on Visual Performance.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Continuous Accelerometry-Based Tremor Detection During Daily Living.

Sensors (Basel, Switzerland)·2026
Same author

Combination of the Fibrosis 4 Index and Carbohydrate Antigen 125 to Predict Morbidity and Mortality in Acute Heart Failure.

Reviews in cardiovascular medicine·2026
Same author

The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: May 28, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Effect of Vibration Anesthesia on Injection-Related Pain: A Prospective Crossover Study.

Luis Martinez1, Dontia Orey2, Gian Troche1

  • 1Universal Axon Clinical Research, Doral, FL, USA.

Journal of Pain Research
|May 27, 2026
PubMed
Summary

Vibration anesthesia using the DigiVibe device significantly reduced pain from needle procedures like injections and fingersticks. This non-pharmacologic method offers a safe way to improve patient comfort during medical care.

Keywords:
injection-related painvibration anesthesia

More Related Videos

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Related Experiment Videos

Last Updated: May 28, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Area of Science:

  • Pain Management
  • Medical Devices
  • Anesthesia

Background:

  • Needle-based procedures (IM, SC injections, fingersticks) cause pain and anxiety.
  • Vibration anesthesia uses gate control theory to reduce pain signals.
  • DigiVibe is an FDA-registered handheld device for mitigating needle-related pain.

Purpose of the Study:

  • To evaluate the effectiveness of the DigiVibe device in reducing pain during common needle procedures.
  • To assess patient-reported pain levels with and without vibration anesthesia.

Main Methods:

  • 20 healthy adults with needle aversion participated.
  • Procedures included fingersticks, SC injections, and IM injections, performed with and without DigiVibe.
  • Pain was measured using a 10-point Visual Analog Scale (VAS).

Main Results:

  • DigiVibe significantly reduced pain across all procedure types (p<0.001).
  • Mean VAS reductions were -2.65 for SC, -2.00 for IM, and -1.75 for fingersticks.
  • 65% experienced no pain during fingersticks; 95% had ≥30% pain reduction for SC injections. No adverse events were reported.

Conclusions:

  • DigiVibe provides statistically significant and clinically meaningful pain reduction.
  • Vibration anesthesia is a safe, non-pharmacologic option to enhance comfort.
  • This method may improve adherence to necessary needle-based medical care.