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Genetically Predicted Use of Common Analgesics and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional
1Department of Integrated Traditional Chinese and Western Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan, 415000 People's Republic of China.
Summary
Common analgesic use and COPD risk were investigated. Paracetamol use may increase COPD risk, while aspirin use may decrease it, suggesting implications for analgesic choice in COPD prevention.
Area of Science:
- Pharmacogenomics
- Respiratory Medicine
- Epidemiology
Background:
- Observational studies suggest a link between analgesic use and chronic obstructive pulmonary disease (COPD).
- Causality between common analgesic use and COPD risk remains unclear.
- This study addresses the need for causal inference in the analgesic-COPD relationship.
Purpose of the Study:
- To investigate the bidirectional causal relationship between genetically predicted use of paracetamol, aspirin, and ibuprofen, and COPD risk.
- To employ a two-sample Mendelian randomization (MR) approach for robust causal inference.
- To assess whether COPD risk influences the use of these common analgesics.
Main Methods:
- A bidirectional MR study utilizing summary statistics from large-scale genome-wide association studies (GWAS).
- Genetic instruments for analgesic use derived from UK Biobank (N=457,547); COPD data from FinnGen consortium (24,138 cases, 409,070 controls).
- Primary analysis via inverse-variance weighted (IVW) method with extensive sensitivity analyses (MR-Egger, weighted median, etc.) to ensure result validity.
Main Results:
- Genetically predicted paracetamol use showed a significant association with increased COPD risk (IVW OR: 6.00).
- Genetically predicted aspirin use was significantly associated with decreased COPD risk (IVW OR: 0.19).
- Genetically predicted ibuprofen use and COPD liability showed no significant causal associations with analgesic use.
Conclusions:
- This MR study provides genetic evidence for a causal link between paracetamol use and higher COPD risk.
- Genetic evidence supports a causal link between aspirin use and lower COPD risk.
- Analgesic choice may significantly impact COPD risk, meriting further clinical research.
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