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Illness Perception and Medication Adherence Trajectories in Patients with Acute Coronary Syndrome: A 6-Month

Qiuhua Xue1, Chan Wu1, Guangsu Qu1

  • 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Patient Preference and Adherence
|May 27, 2026
PubMed

Insights

Illness perception and medication adherence in acute coronary syndrome patients show reciprocal predictive relationships over time. Understanding these dynamics is key for improving patient outcomes and treatment adherence.

Area of Science:

  • Cardiology
  • Psychology
  • Health Sciences

Background:

  • Acute coronary syndrome (ACS) poses significant health challenges.
  • Effective management requires understanding patient factors influencing recovery, such as illness perception and medication adherence.

Purpose of the Study:

  • To investigate the longitudinal trajectories of illness perception and medication adherence in ACS patients.
  • To examine the predictive relationship between illness perception and medication adherence over a 6-month period.

Main Methods:

  • 311 ACS patients were assessed at baseline, 3 months, and 6 months post-onset.
  • Data collected using the Brief Illness Perception Questionnaire (BIPQ) and Medication Adherence Rating Scale (MARS).
  • Cross-lagged panel modeling (CLPM) and parallel latent growth modeling (LGM) were employed.

Main Results:

  • Illness perception and medication adherence scores significantly decreased from baseline to 6 months.
  • Significant reciprocal relationships were found: illness perception predicted adherence, and adherence predicted illness perception.
  • Higher initial illness perception negatively predicted its own slope and the slope of medication adherence.

Conclusions:

  • Illness perception and medication adherence in ACS patients exhibit dynamic, interconnected trajectories.
  • These factors demonstrate a significant bidirectional predictive relationship, highlighting their importance in patient management.
  • Interventions targeting illness perception may positively influence medication adherence in ACS patients.
Abstract

Keywords:
acute coronary syndromecorrelationcross-lag modelillness perceptionmedication adherenceparallel latent variable model

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