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Updated: May 28, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Association of Common Ancestry-Enriched Variants With Cardiomyopathy and Arrhythmias

Temidayo A Abe1, Megan C Lancaster1,2, Dan M Roden3

  • 1Division of Cardiovascular Medicine, Department of Medicine (T.A.A., M.C.L.), Vanderbilt University Medical Center, Nashville, TN.

Circulation
|May 27, 2026
PubMed
Summary

Genetic variants of uncertain significance (VUS) enriched in individuals of African ancestry are linked to increased cardiovascular risk, including cardiomyopathies and arrhythmias. These risks are amplified by heart failure and other cardiovascular risk factors.

Keywords:
arrhythmias, cardiaccardiomyopathiesdeath, sudden, cardiacracial groups

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